How does Denosyl work?
Denosyl has been shown to markedly increase liver glutathione levels,1,2 an important compound for liver health formed when SAMe is metabolized .
Denosyl has also been shown to help protect liver cells from cell death3,4 and may help cell repair and regeneration.5
While best known for supporting the liver in dogs and cats Denosyl also has a place in supporting brain health! Denosyl could help your best friend live a longer, healthier life.
Research is looking into dog aging and associated decreases in levels of SAMe (S-Adenosylmethionine) in cerebrospinal fluid, which surrounds the brain. Denosyl provides SAMe in a stabilized form to help with brain health and act as a neuroprotector.
The new chewable tablets of Denosyl allow dogs to receive SAMe in a tasty treat eliminating the need to "pill" your dog daily. Additionally, the chewable tablets are absorbed more quickly when compared to hard enteric-coated tablets.
What is this product used for:
Denosyl has been shown to increase hepatic glutathione levels in cats and dogs. Glutathione is a potent antioxidant that protects liver cells from toxins and death. Denosyl is recommended to improve hepatic glutathione levels in compromised animals to help maintain and protect liver function.
Denosyl is a non-prescription (OTC) product available as 90mg, 225mg and 425mg stabilized tablets.
How this product should be used:
The tablets should be given on an empty stomach at least one hour before feeding. Research shows that, if possible, a fasting period of 8-12 hours before giving this product is optimal. The usual dose in cats and dogs is based on weight. For pets up to 12 lbs give 1 tablet of the 90mg strength, for pets 13 to 34 lbs give 1 tablet of the 225mg strength, for pets 35 to 65 lbs give 1 tablet of the 425mg strength, for pets 66 to 120 lbs give 2 tablets of the 425mg strength and for pets over 120 lbs give 3 tablets of the 425mg strength. When giving more than 1 tablet the total number of tablets may be divided into morning and evening. For example, a dose of 3 tablets could be divided into 2 tablets in the morning and 1 tablet in the evening.
What are the side effects:
There are no reported side effects.
What special precautions are there:
Tablets must be given whole. Do not break or split. Research shows that this product may be of benefit to pets that are also taking primidone, Phenobarbital, prednisone, azathioprine, cyclosporine and certain anti-depressants.
In the event of overdose:
Contact a veterinarian or veterinary emergency room.
How should I store this product:
Store this product in a cool, dry, place. Keep tablets in the original blister pack until used. Tablets are sensitive to moisture and extreme heat and should not be split or crumbled. Keep out of the reach of children.
This information sheet is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet.
The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian.
Note: Any trademarks are the property of their respective companies
- Center SA, Warner K, Hoffman WE, et al. Am J Vet Res 2005;66:330-341.
- Center SA, Randolph JF, Warner K, et al. J Vet Intern Med 2005;19:303-314.
- Webster CRL, Boria P, Usechak P, et al. Vet Therapeutics 2002;3:474-484.
- McCool J, Johnston A, Webster CRL. In Proceedings. 21st Annual ACVIM Forum 2003;abstract #134.
- Center SA. In Proceedings. 18th Annual ACVIM Forum 2000;550-552.
†Source: Survey conducted in February 2007 of small animal veterinarians who recommended liver support brands.
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